1、The constant criticism from his boss disaffected him, and he eventually quit his job.
来自老板的持续批评让他感到不满，最终他辞职了。

2、The government's failure to address the concerns of the marginalized groups is likely to disaffect them and lead to social unrest.
政府未能解决边缘群体的关切可能会使他们不满，并导致社会动荡。